Pierre Gressens Selected Research

Benzamidines

7/2010

1,2-ethane bis-1-amino-4-benzamidine is active against several brain insult and seizure challenges through anti-NMDA mechanisms targeting the 3H-TCP binding site and antioxidant action.

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Pierre Gressens Research Topics

Disease

40	Brain Injuries (Brain Injury) 10/2021 - 01/2002
37	Inflammation (Inflammations) 04/2022 - 02/2007
22	Hypoxia (Hypoxemia) 01/2021 - 12/2002
14	Cerebral Palsy (Spastic Diplegia) 01/2020 - 01/2002
13	Brain Diseases (Brain Disorder) 01/2022 - 01/2012
13	Ischemia 01/2020 - 03/2003
12	Microcephaly 01/2020 - 03/2010
12	Infections 01/2019 - 03/2007
10	Cysts 02/2012 - 01/2002
9	Neuroinflammatory Diseases 01/2021 - 01/2017
9	Asphyxia (Suffocation) 01/2020 - 06/2006
7	Seizures (Absence Seizure) 10/2021 - 04/2008
6	Hypothermia 01/2017 - 01/2008
5	Premature Birth (Birth, Premature) 04/2022 - 10/2011
5	Intellectual Disability (Idiocy) 01/2018 - 02/2009
5	Necrosis 01/2017 - 02/2003
5	Stroke (Strokes) 01/2015 - 09/2005
4	Gliosis 01/2022 - 10/2008
4	Neoplasms (Cancer) 01/2018 - 01/2012
4	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2013 - 06/2006
3	Premature Obstetric Labor (Premature Labor) 04/2022 - 11/2018
3	Neurodevelopmental Disorders 03/2022 - 01/2015
3	Brain Hypoxia-Ischemia (Hypoxia Ischemia, Brain) 11/2018 - 01/2016
3	Tuberculosis (Tuberculoses) 01/2017 - 01/2014
3	Wounds and Injuries (Trauma) 03/2013 - 09/2007
3	Periventricular Leukomalacia (Neonatal Cerebral Leukomalacia) 06/2008 - 01/2002
2	Epilepsy (Aura) 01/2018 - 08/2015
2	Body Weight (Weight, Body) 01/2018 - 12/2002
2	Demyelinating Diseases (Demyelinating Disease) 01/2017 - 09/2009
2	Encephalitis (Encephalitis, Rasmussen) 12/2016 - 10/2016
2	Malnutrition (Nutritional Deficiencies) 12/2016 - 04/2012
2	Perinatal Death 08/2016 - 12/2002
2	Dwarfism 08/2016 - 02/2009
2	Dyggve-Melchior-Clausen syndrome 05/2015 - 02/2009
2	Lissencephaly 12/2012 - 04/2006
2	Parkinson Disease (Parkinson's Disease) 02/2012 - 07/2007
2	Cerebral Infarction 11/2011 - 06/2004
2	Sepsis (Septicemia) 07/2011 - 02/2011

Drug/Important Bio-Agent (IBA)

15	Proteins (Proteins, Gene)FDA Link 12/2019 - 02/2009
14	CytokinesIBA 01/2021 - 03/2003
13	Neuroprotective AgentsIBA 01/2021 - 02/2003
10	Biomarkers (Surrogate Marker)IBA 01/2021 - 01/2012
10	N-Methylaspartate (NMDA)IBA 10/2014 - 01/2002
9	MelatoninIBA 11/2021 - 01/2002
8	Caspase 3 (Caspase-3)IBA 01/2022 - 11/2005
8	Glutamic Acid (Glutamate)FDA Link 06/2008 - 01/2002
7	Oxygen (Dioxygen)IBA 01/2021 - 02/2009
7	LipopolysaccharidesIBA 01/2019 - 02/2008
6	Dexmedetomidine FDA Link 01/2017 - 01/2002
6	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 10/2012 - 01/2002
6	alpha- Amino- 3- hydroxy- 5- methyl- 4- isoxazolepropionic Acid (AMPA)IBA 01/2011 - 09/2005
5	ChemokinesIBA 01/2021 - 01/2014
4	Pharmaceutical PreparationsIBA 04/2022 - 02/2003
4	DNA Nucleotidylexotransferase (Terminal Deoxynucleotidyl Transferase)IBA 01/2022 - 03/2006
4	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2015 - 05/2011
4	Kainic Acid Receptors (Kainate Receptor)IBA 01/2011 - 12/2005
3	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2021 - 07/2008
3	Glucose (Dextrose)FDA LinkGeneric 01/2021 - 02/2009
3	MagnesiumIBA 01/2019 - 04/2008
3	Transcription Factors (Transcription Factor)IBA 01/2017 - 05/2012
3	Lactic Acid (Lactate)FDA LinkGeneric 03/2016 - 01/2007
3	LigandsIBA 08/2015 - 04/2008
3	Free RadicalsIBA 07/2004 - 01/2002
2	Fatty Acids (Saturated Fatty Acids)IBA 01/2022 - 01/2018
2	Interleukin-1beta (Interleukin 1 beta)IBA 01/2022 - 02/2008
2	Anticonvulsants (Antiepileptic Drugs)IBA 10/2021 - 04/2012
2	Interleukin-10 (Interleukin 10)IBA 01/2021 - 03/2003
2	MicroRNAs (MicroRNA)IBA 01/2021 - 01/2021
2	Messenger RNA (mRNA)IBA 01/2021 - 07/2008
2	Ethanol (Ethyl Alcohol)IBA 01/2020 - 01/2007
2	Magnesium Sulfate (Sulfate, Magnesium)FDA LinkGeneric 01/2019 - 06/2008
2	Erythropoietin FDA Link 04/2018 - 11/2006
2	Clodronic Acid (Clodronate)IBA 01/2018 - 03/2013
2	Phosphotransferases (Kinase)IBA 10/2017 - 02/2009
2	Isoflurane FDA LinkGeneric 01/2017 - 01/2017
2	Protons (Proton)IBA 03/2016 - 01/2013
2	N-acetylaspartate (N-acetyl aspartate)IBA 03/2016 - 01/2013
2	Somatostatin (Somatotropin Release-Inhibiting Factor)IBA 08/2015 - 01/2011
2	Interleukin-13IBA 08/2015 - 01/2014
2	Interleukin-2 (IL2)IBA 08/2015 - 01/2014
2	Interleukin-5 (Interleukin 5)IBA 08/2015 - 01/2014
2	NF-kappa B (NF-kB)IBA 01/2015 - 01/2015
2	deoxyuridine triphosphateIBA 01/2015 - 01/2011
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 03/2014 - 07/2010
2	Thyroid HormonesIBA 03/2014 - 05/2007
2	Pentylenetetrazole (Metrazol)IBA 12/2013 - 07/2010
2	GlucocorticoidsIBA 06/2013 - 10/2011
2	Metabotropic Glutamate Receptors (Metabotropic Glutamate Receptor)IBA 05/2013 - 03/2005
2	Brain-Derived Neurotrophic Factor (BDNF)IBA 05/2013 - 02/2012
2	Superoxides (Superoxide)IBA 01/2013 - 07/2010
2	Caspase 2IBA 05/2012 - 11/2011
2	Matrix Metalloproteinases (MMPs)IBA 01/2012 - 03/2009
2	salicylhydroxamic acid (SHAM)IBA 09/2011 - 01/2008
2	Topiramate (Topamax)FDA LinkGeneric 01/2011 - 12/2005

Therapy/Procedure

16	Therapeutics 11/2021 - 01/2005
6	Induced Hypothermia 01/2022 - 01/2013
4	Intraperitoneal Injections 01/2021 - 02/2006
4	Injections 01/2019 - 12/2002
3	Ligation 11/2018 - 09/2009
2	Protein-Restricted Diet (Diet, Protein Restricted) 01/2019 - 12/2016